Mammary Analogue Secretory Carcinoma of Salivary Gland – A Diagnostic Dilemma
Published: December 1, 2017 | DOI: https://doi.org/10.7860/JCDR/2017/32246.10961
Chetan S Chaudhari, Shruti Chandrakar, Ganesh R Kshirsagar, Prashant V Kumavat, Nitin M Gadgil
1. Assistant Professor, Department of Pathology, Lokmanya Tilak Municipal Medical College, Mumbai, Maharashtra, India.
2. Senior Resident, Department of Pathology, Lokmanya Tilak Municipal Medical College, Mumbai, Maharashtra, India.
3. Assistant Professor, Department of Pathology, Lokmanya Tilak Municipal Medical College, Mumbai, Maharashtra, India.
4. Assistant Professor, Department of Pathology, Lokmanya Tilak Municipal Medical College, Mumbai, Maharashtra, India.
5. Associate Professor, Department of Pathology, Lokmanya Tilak Municipal Medical College, Mumbai, Maharashtra, India.
Correspondence
Dr. Shruti Chandrakar,
34, A/1, Maulshree Vihar, VIP Road, Raipur-492006, Chhattisgarh, India.
E-mail: shrutichandrakar9388@gmail.com
Mammary Analogue Secretory Carcinoma (MASC) of salivary gland is a recently described entity with unique morphologic, clinical and genetic characteristics, including the characteristic t(12;15)(p13;q25) with ETV6-NTRK3 translocation found in secretory carcinomas of the breast. Before their initial description, these salivary gland tumours were generally diagnosed as acinic cell carcinoma or adenocarcinoma. We present a case of 32-year-old, male presenting with painless swelling over left cheek which was gradually increasing in size. The histopathological examination of the lesion was done and two possible differential diagnosis were acinic cell carcinoma (papillary cystic variant) and MASC of the parotid gland. Immunohistochemistry was performed which demonstrated combined positivity for S-100, mammglobin, CK-7 and DOG-1 negativity which confirmed the diagnosis of MASC of parotid.
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